![]() Advise patients to rinse their mouths with water without swallowing after inhalation. ![]() Oropharyngeal candidiasis has occurred in patients treated with orally inhaled drug products containing fluticasone furoate.Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs, like LABA. TRELEGY should not be used more often or at higher doses than recommended or with another LABA for any reason, as an overdose may result.Acute symptoms should be treated with an inhaled, short-acting beta 2-agonist. TRELEGY is NOT a rescue medication and should NOT be used for the relief of acute bronchospasm or symptoms.TRELEGY should NOT be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of COPD or asthma.TRELEGY is not indicated for use in pediatric patients aged 17 years and younger. When LABA are used in fixed-dose combination with inhaled corticosteroids (ICS), data from large clinical trials do not show a significant increase in the risk of serious asthma-related events (hospitalizations, intubations, death) compared with ICS alone. These findings are considered a class effect of LABA monotherapy. Long-acting beta 2-adrenergic agonist (LABA) monotherapy for asthma increases the risk of asthma-related death, and in pediatric and adolescent patients, available data also suggest an increased risk of asthma-related hospitalization.Patients with severe hypersensitivity to milk proteins or demonstrated hypersensitivity to fluticasone furoate (FF), umeclidinium (UMEC), vilanterol (VI), or any of the excipients.Primary treatment of status asthmaticus or other acute episodes of COPD or asthma where intensive measures are required.2012 106(3):382–389.TRELEGY is contraindicated in the following: Comparison of tiotropium plus fluticasone propionate/salmeterol with tiotropium in COPD: a randomized controlled study. Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD. Hanania NA, Crater GD, Morris AN, Emmett AH, O’Dell DM, Niewoehner DE. A pilot study to assess the effects of combining fluticasone propionate/salmeterol and tiotropium on the airflow obstruction of patients with severe-to-very severe COPD. National Center for Chronic Disease Prevention and Health Promotion Division of Population Health. ĬDC Chronic Obstructive Pulmonary Disease (COPD). GOLD Global strategy for the diagnosis, management and prevention of COPD. Reducing the number of inhalers may improve overall adherence to intended triple therapy.ĬOPD ICS LABA LAMA chronic obstructive pulmonary disease inhaled corticosteroids long-acting muscarinic antagonists long-acting β2-agonists medication adherence multiple inhaler triple therapy. Mean PDC for each single inhaler component was higher than the mean PDC observed with MITT. Patients with COPD had low adherence to and persistence with MITT in a real-world setting. Allowing for a 30-day gap from last day of therapy, 86% of MITT users discontinued therapy during follow-up. The proportion of adherent patients (PDC ≥0.8) at 12 months was 14% for MITT. Mean PDC for MITT at 12 months was 0.37%. In total, 14,635 MITT users were identified (mean age, 62 years). In addition, analyses were stratified by number of inhalers. Adherence (proportion of days covered, PDC) and discontinuation (defined as a gap of 1, 30, 60, or 90 days of supply in any of the three components of the triple therapy) were calculated for each patient over 12 months of follow-up. MITT was defined as subjects with ≥1 overlapping days' supply of three COPD medications (ICS, LABA, and LAMA). Patients aged ≥40 years receiving MITT between January 2012 and September 2015 were identified from the IQVIA™ Real-world Data Adjudicated Claims-USA database. This longitudinal, retrospective cohort study of patients with COPD describes baseline characteristics, adherence, and persistence following initiation of inhaled corticosteroids (ICS)/long-acting β 2-agonists (LABA)/long-acting muscarinic antagonists (LAMA) from multiple inhaler triple therapy (MITT).
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